NCE Discovery

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Poziotinib

  • Irreversible potent pan-Her inhibitor
  • Effective and tolerable for Her-2 & EGFR driven cancers
  • Excellent in vivo efficacy in Xenograft model of Her-related cancer cells

HM61713

  • Selective & Excellent activity to EGFR mutants including T790M
  • No event of diarrhea or rash caused by EGFR WT
  • Clinical trial conducting in advanced NSCLC patients with EGFR mutations

HM71224

  • Irreversibly designed BTK inhibitor
  • Potent inhibition of BTK signaling in B cell such as p-BTK and p-PLC款
  • Phase 1 clinical study is ongoing in rheumatoid arthritis and scheduled in lymphoma