R&D

Pipeline

New Drug Development Status

category

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BBeijing Hanmi’s Pipeline

Last updated 2018-04-22
Phase 3

  • efpeglenatide(LAPSExd4 Analog)

    efpeglenatide (LAPSExd4 Analog)
    Synonyms
    efpeglenatide (rINN); HM11260C; SAR-439977; LAPS-Exd4 Analog; LAPS-Exendin-4 Analog; LAPS-CA-Exd4; LAPS-CA-Exendin-4 Analog; langlenatide
    Mechanism & Characteristic
    A long-acting exendin-4 analog as a Glucagon-like peptide-1 (GLP-1) receptor agonist; Superior blood glucose lowering efficacy via less GLP-1R desensitization; Once weekly~monthly administration (best-in-class potential)
    Therapeutic Area
    Metabolic disease
    Indication
    Diabetes & Obesity
    Status
    Phase 3
    Molecule Type
    Biologic
    Technology
    LAPSCOVERY™ platform
    Collaboration Partners
    Sanofi (Code: SAR-439977)
    Additional Information
    Poster presentation at ADA in 2016 [download]

    Sanofi

  • Rolontis™(eflapegrastim)

    Rolontis™ (eflapegrastim)
    Synonyms
    Rolontis; eflapegrastim (rINN/USAN); HM10460A; SPI-2012; LAPS-GCSF Analog
    Mechanism & Characteristic
    A long-acting Granulocyte-Colony Stimulating Factor (G-CSF) analog; Every three weeks administration
    Therapeutic Area
    Oncology
    Indication
    Chemotherapy-induced neutropenia
    Status
    Phase 3
    Molecule Type
    Biologic
    Technology
    LAPSCOVERY™ platform
    Collaboration Partners
    Spectrum Pharmaceuticals (Code: SPI-2012)

    Zailab

  • Oraxol™(Paclitaxel + HM30181A)

    Oraxol™
    Synonyms
    Oraxol; paclitaxel+HM30181A; paclitaxel+HM30181AK; paclitaxel+HM30181AK-US
    Mechanism & Characteristic
    A combination formulation composed of the taxane compound paclitaxel and the multidrug resistance (MDR) efflux pump P-glycoprotein (P-gp) inhibitor HM30181A, with potential antineoplastic activity expecting reduced side effects and low neurotoxicity
    Therapeutic Area
    Oncology
    Indication
    Solid tumors / Breast cancer
    Status
    Phase 3
    Molecule Type
    Combination (small molecule)
    Technology
    ORASCOVERY™ platform (Oral Absorption Enhancing Drug Delivery Technology)
    Collaboration Partners
    Athenex

    Athenex

Phase 2

  • HM12525A(LAPSGLP/GCG)

    HM12525A (LAPSGLP/GCG)
    Synonyms
    HM12525A; JNJ-64565111; LAPS-GLP/GCG; LAPS-GLP-1/GCG; LAPS-OXM
    Mechanism & Charactersitic
    A long-acting GLP-1 & glucagon dual receptor agonist; Improving multiple metabolic parameters that lead to improved blood glucose, body weight, and insulin sensitivity; Once weekly administration
    Therapeutic Area
    Metabolic disease
    Indication
    Diabetes & Obesity
    Status
    Phase 2
    Molecule Type
    Biologic
    Technology
    LAPSCOVERY™ platform
    Collaboration Partners
    Janssen (Code: JNJ-64565111)
    Additional Information
    Poster presentation at ADA in 2016 [download]

    Janssen

  • poziotinib(pan-HER)

    poziotinib (pan-HER)
    Synonyms
    poziotinib (rINN); HM781-36B; HM781-36
    Mechanism & Characteristic
    A pan-HER inhibitor that irreversibly blocks signaling through the HER family of tyrosine-kinase receptors including HER1 (erbB1; EGFR), HER2 (erbB2), and HER4 (erbB4), as well as HER receptor mutations
    Therapeutic Area
    Oncology
    Indication
    Solid tumors (breast, lung cancer)
    Status
    Phase 2 (Pre-Phase 1 in CN)
    Molecule Type
    Small molecule
    Collaboration Partners
    Spectrum Pharmaceuticals in WW (except CN, KR); Luye Pharma in CN
    Additional Information
    Poster presentation at ASCO in 2015 [download]

    Spectrum|Luye

  • HM71224(BTK)

    HM71224 (BTK)
    Synonyms
    HM71224; LY3337641
    Mechanism & Charactersitic
    Bruton's tyrosine kinase (BTK) inhibitor
    Therapeutic Area
    Autoimmune disease
    Status
    Phase 2 (began in August 2016 in patients with rheumatoid arthritis)
    Molecule Type
    Small molecule
    Collaboration Partners
    Eli Lilly (Code: LY3337641)
    Additional Information
    Poster presentation at EULAR in 2015 [download]

    Zailab

  • efpegsomatropin(LAPShGH)

    efpegsomatropin (LAPShGH)
    Synonyms
    efpegsomatropin (rINN); HM10560A; LAPS-hGH; LAPS-rhGH
    Mechanism & Characteristic
    A long-acting recombinant human growth hormone; Once weekly administration
    Therapeutic Area
    Endocrinology
    Indication
    Growth hormone deficiency
    Status
    Phase 2
    Molecule Type
    Biologic
    Technology
    LAPSCOVERY™ platform
    Additional Information
    Poster presentation at ENDO in 2015 [download]

  • Luminate®(ALG-1001)

    Luminate® (ALG-1001)
    Synonyms
    Luminate; ALG-1001
    Mechanism & Charactersitic
    Integrin modulator; Anti-angiogenesis and vitreolysis
    Therapeutic Area
    Ophthalmologic disease
    Indication
    Retina disease (diabetic macular edema, etc.)
    Status
    Phase 2
    Molecule Type
    Small molecule (peptide)
    Collaboration Partners
    Allegro ophthalmics

    Zailab

Phase 1

  • HM15211(LAPSTriple Agonist)

    HM15211 (LAPSTriple Agonist)
    Mechanism & Characteristic
    A long-acting GLP-1, GIP and glucagon triple agonist; Targeting once weekly administration
    Therapeutic Area
    Metabolic disease
    Indication
    Obesity,NASH
    Status
    Phase 1
    Molecule Type
    Biologic
    Technology
    LAPSCOVERY™ platform
    Additional Information
    Poster presentation at ADA in 2017 [download]

  • HM12460A / HM12470(LAPSInsulin / LAPSInsulin Analog)

    HM12460A / HM12470
    (LAPSInsulin / LAPSInsulin Analog)
    Synonyms
    LAPS-Insulin; HM12460A / LAPS-Insulin115; HM12470; SAR440067
    Mechanism & Characteristic
    A long-acting insulin or insulin analog; Once weekly administration
    Therapeutic Area:
    Metabolic disease
    Indication
    Type 1 & 2 Diabetes
    Status
    Phase 1
    Technology
    LAPSCOVERY™ platform
    Additional Information:
    Poster presentation at ADA in 2016 [download]

  • HM95573(RAF)

    HM95573 (RAF)
    Synonyms
    HM95573; RG6185
    Mechanism & Charactersitic
    Rapidly Accelerated Fibrosarcoma (RAF) inhibitor; BRAF mutation & N-RAS mutation driven cancer
    Therapeutic Area
    Oncology
    Indication
    Solid tumors
    Status
    Phase 1
    Molecule Type
    Small molecule
    Collaboration Partners
    Roche/Genentech (Code: RG6185)
    Additional Information
    Poster presentation at ASCO in 2016 [download]
    Poster presentation at EORTC in 2016 [download]

    Genentech

  • Oratecan™(Irinotecan + HM30181A)

    Oratecan™
    Synonyms
    Oratecan; irinotecan+HM30181A; irinotecan+HM30181AK; irinotecan+HM30181AK-US
    Mechanism & Characteristic
    Irinotecan with an oral absorption enhancer (P-gp inhibitor, HM30181A); A combination formulation composed of the irinotecan and the multidrug resistance (MDR) efflux pump P-glycoprotein (P-gp) inhibitor HM30181A with potential antineoplastic activity having reduced side effects
    Therapeutic Area
    Oncology
    Indication
    Solid tumors (colorectal cancer, etc.)
    Status
    Phase 1
    Molecule Type
    Combination (small molecule)
    Technology
    ORASCOVERY™ platform (Oral Absorption Enhancing Drug Delivery Technology)
    Collaboration Partners
    Athenex

    Athenex

  • KX2-391(Src/Tubulin)

    KX2-391 (Src/Tubulin)
    Synonyms
    KX2-391; KX-01
    Mechanism & Charactersitic
    Src inhibitor and tubulin destabilizer
    Therapeutic Area
    Oncology
    Indication
    Solid tumors
    Status
    Phase 1
    Molecule Type
    Small molecule
    Collaboration Partners
    Athenex

    Athenex

Pre-clinical

  • HM14220(LAPSInsulin Combo)

    HM14220 (LAPSInsulin Combo)
    Mechanism & Characteristic
    Combination of a long-acting insulin analog and a long-acting exendin-4 analog; Targeting once weekly administration
    Therapeutic Area
    Metabolic disease
    Indication
    Type 2 Diabetes
    Status
    Pre-clinical
    Molecule Type
    Combination (biologic)
    Technology
    LAPSCOVERY™ platform
    Collaboration Partners
    Sanofi

    Sanofi

  • HM15136(LAPSGlucagon Analog)

    HM15136 (LAPSGlucagon Analog)
    Mechanism & Characteristic
    A long-acting glucagon analog; Targeting once weekly administration
    Therapeutic Area
    Rare disease
    Indication
    Cogenitial Hyperinsulinism (CHI)
    Status
    Pre-clinical(Phase 1 IND submission planned in 4Q 2017~2Q 2018)
    Molecule Type
    Biologic
    Technology
    LAPSCOVERY™ platform
    Additional Information
    Poster presentation at ADA in 2017 [download]

  • HM15450(LAPSASB)

    HM15450 (LAPSASB)
    Mechanism & Characteristic
    Long-acting enzyme replacement therapy (ERT); Targeting once monthly administration
    Therapeutic Area
    Rare disease
    Indication
    Mucopolysaccharidosis
    Status
    Pre-clinical
    Molecule Type
    Biologic
    Technology
    LAPSCOVERY™ platform

  • HM15912(LAPSGLP-2 Analog)

    HM15912 (LAPSGLP-2 Analog)
    Mechanism & Characteristic
    Long-acting Glucagon-like peptide 2 (GLP-2) analog; Targeting once weekly administration
    Therapeutic Area
    Rare disease
    Indication
    Short bowel syndrome
    Status
    Pre-clinical
    Molecule Type
    Biologic
    Technology
    LAPSCOVERY™ platform

  • HM43239(FLT3)

    HM43239 (FLT3)
    Mechanism & Characteristic
    FMS-like tyrosine kinase 3 (FLT-3) inhibitor
    Therapeutic Area
    Oncology
    Indication
    AML (Acute Myeloblastic Leukemia)
    Status
    Pre-clinical
    Molecule Type
    Small molecule

  • HM81442(FGFR4)

    HM81442 (FGFR4)
    Mechanism & Characteristic
    Fibroblast growth factor receptor 4 (FGFR4) inhibitor
    Therapeutic Area
    Oncology
    Indication
    HCC (Hepatocellular Carcinoma)
    Status
    Pre-clinical
    Molecule Type
    Small molecule

  • LSD1

    LSD1
    Mechanism & Characteristic
    Lysine-specific histone demethylase 1 (LSD1) inhibitor
    Therapeutic Area
    Oncology
    Indication
    SCLC (Small Cell Lung Cancer)
    Status
    Pre-clinical
    Molecule Type
    Small molecule

  • HM21001(GBM Stem Cell Therapy)

    HM21001 (GBM Stem Cell Therapy)
    Mechanism & Characteristic
    Glioblastoma (GBM) stem cell therapy
    Therapeutic Area
    Oncology
    Indication
    Glioblastoma
    Status
    Pre-clinical
    Molecule Type
    Biologic
    Collaboration Partners
    Ajou University

    아주대 병원

  • PD-1/TAA1Targeted Immuno-oncology

    PD-1/TAA1 Bispecific Antibody
    Mechanism & Characteristic
    A bispecific antibody for targeted immuno-oncology
    Therapeutic Area
    Solid tumor
    Status
    Pre-clinical
    Molecule Type
    Biologic (BsAb)
    Technology
    PENTAMBODY™ platform

    Innovent

  • PD-1/TAA2Targeted Immuno-oncology

    PD-1/TAA2 Bispecific Antibody
    Mechanism & Characteristic
    A bispecific antibody for targeted immuno-oncology
    Therapeutic Area
    Solid tumor
    Status
    Pre-clinical
    Molecule Type
    Biologic (BsAb)
    Technology
    PENTAMBODY™ platform

  • PD-1/TAA3Targeted Immuno-oncology

    PD-1/TAA3 Bispecific Antibody
    Mechanism & Characteristic
    A bispecific antibody for targeted immuno-oncology
    Therapeutic Area
    Solid tumor
    Status
    Pre-clinical
    Molecule Type
    Biologic (BsAb)
    Technology
    PENTAMBODY™ platform